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ご参考まで．（重複ご容赦）
-----Original Message-----
From: Yoshihiro Murayama [mailto:murayama@***.***]
Sent: Tuesday, July 01, 2003 11:18 AM
To: seminar@***.***
Cc: seminar; seminar_info
Subject: Sano Lab Seminar 2003.07.11
佐野研セミナー＠東大理のお知らせです．
皆様奮ってご参加ください．
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日時：７月１１日（金） １６：３０?
場所：東京大学理学部１号館２階２０１a号室
講演者： 澤井 哲 氏
(Princeton University, Department of Molecular Biology)
"The early cAMP wave propagation in Dictyostelium revisited:
phenomenology and genetic dissection"
We have characterized the early wave phenomena observed by means of
dark-field optics for wild-type and mutant strains under various
conditions. Spatial features such as wave geometry and temporal features
such as signal onset time and frequency were analyzed. By testing
different initial conditions, we see how heterogeneity of cells along
the developmental path correlates with appearance of spiral waves. We
will also introduce wave phenotypes of regA, rdeC and other mutant
strains having defects in the feedback module of the oscillatory
circuit. These cell lines each have a distinct and characteristic
behavior such as propagating plateau, labyrinthine pattern and loss of
oscillation. Our findings provide a basis for understanding the design
principle behind the oscillatory circuit as well as proof of principle
for the high-throughput phenotyping based on wave dynamics that is
currently underway in our group.
粘菌の集合初期の光学密度波に基づいた表現型のランドスケープを、１０００以
上の
欠損株をもとに探索しています。今回はその基礎付けとして、らせん波の起源と
振動
モデルの実験検証についてお話しします。
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連絡先
村山 能宏 (Yoshihiro Murayama)
E-mail: murayama@***.***
Phone: 03-5841-4183
東京大学大学院理学系研究科 物理学専攻 佐野研究室
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